In the early years of the AIDS epidemic, the disease was considered a death sentence affecting communities, like the LGBT ones, whom many in power felt deserved it. This film tells the story of how militant activists like ACT-UP and TAG pushed for a meaningful response to this serious public health problem. As the activists struggled against political indifference, religious hostility, corporate greed and apparently skewed scientific research priorities with determination and sheer audacity, they produced a political wave that would lead to not only an effective treatment regime, but would advance LGBT rights beyond anyone's expectations.